Friday, November 18, 2011

Predicting How Individuals Differ from Their Genome Sequences

Predicting How Individuals Differ from Their Genome Sequences

It now only costs a few thousand Euros to sequence the genome of an individual human. However, for most of us, knowing our genome sequence would not be useful. Each human has more than 20 000 genes, and in each of us several thousand of these genes carry mutations. We do not know what happens when most human genes are altered, which means that we cannot yet make many useful predictions about our health from the sequence of our genome. Put another way, for most common human diseases we do not know most of the genes that are important, and so we cannot predict whether a person will develop a disease from their DNA sequence.

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